Browsing by Author "García Ojalvo, Jordi"

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  • A competitive protein interaction network buffers Oct4-mediated differentiation to promote pluripotency in embryonic stem cells
    Muñoz Descalzo, Silvia; Rué, Pau; Faunes, Fernando; Hayward, Penelope; Jakt, Lars Martin; Balayo, Tina; García Ojalvo, Jordi; Martínez Arias, Alfonso (Nature Publishing Group, 2013)
    Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of 'self-renewal' and 'differentiation' genes. ...
  • A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity
    Picón-Pagès, Pol; Bosch Morató, Mònica, 1986-; Subirana, Laia; Rubio-Moscardó, Francisca; Guivernau Almazán, Biuse, 1988-; Fanlo-Ucar, Hugo; Zeylan, Melisa Ece; Senyuz, Simge; Herrera-Fernández, Víctor; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; García Ojalvo, Jordi; Gursoy, Attila; Keskin, Ozlem; Oliva Miguel, Baldomero; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Muñoz López, Francisco José, 1964- (MDPI, 2023)
    Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried ...
  • A living liquid crystal dissected
    García Ojalvo, Jordi (Nature Research, 2019)
    A large-scale imaging study has tracked thousands of bacteria living in three-dimensional biofilms. This technical tour de force reveals the importance of mechanical interactions between cells for building local and global ...
  • A segmentation clock patterns cellular differentiation in a bacterial biofilm
    Chou, Kwang-Tao; Lee, Dong-yeon D.; Chiou, Jian-Geng; Galera Laporta, Letícia, 1985-; Ly, San; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2022)
    Contrary to multicellular organisms that display segmentation during development, communities of unicellular organisms are believed to be devoid of such sophisticated patterning. Unexpectedly, we find that the gene expression ...
  • A tunable population timer in multicellular consortia
    Toscano Ochoa, Carlos, 1985-; García Ojalvo, Jordi (Elsevier, 2021)
    Processing time-dependent information requires cells to quantify the duration of past regulatory events and program the time span of future signals. At the single-cell level, timer mechanisms can be implemented with genetic ...
  • Analysis of brain dynamics using echo-state networks
    Ibáñez Soria, David, 1983- (Universitat Pompeu Fabra, 2018-09-13)
    In the last decade recurrent neural networks have revolutionized the field of artificial intelligence. Their cyclic connections provide them with memory and thus with the capability of modeling processes with temporal ...
  • Antithetic population response to antibiotics in a polybacterial community
    Galera Laporta, Letícia, 1985-; García Ojalvo, Jordi (American Association for the Advancement of Science (AAAS), 2020)
    Much is known about the effects of antibiotics on isolated bacterial species, but their influence on polybacterial communities is less understood. Here, we study the joint response of a mixed community of nonresistant ...
  • Bistable emergence of oscillations in growing Bacillus subtilis biofilms
    Martínez Corral, Rosa, 1991-; Liu, Jintao; Süel, Gürol M.; García Ojalvo, Jordi (National Academy of Sciences, 2018)
    Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge ...
  • Blood neutrophil counts define specific clusters of bronchiectasis patients: A hint to differential clinical phenotypes
    Wang, Xuejie; Olveira, Casilda; Girón, Rosa; García-Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez-López, Juan; Prados, Concepción; Martínez-González, Miguel A.; Rodriguez, Juan Luis; Rosa, David de la; Qin, Liyun; Duran Jordà, Xavier, 1974-; García Ojalvo, Jordi; Barreiro Portela, Esther (MDPI, 2022)
    We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 ...
  • Characterization of the non-stationary nature of steady-state visual evoked potentials using echo state networks
    Ibáñez Soria, David, 1983-; Soria Frisch, Aureli; García Ojalvo, Jordi; Ruffini, Giulio (Public Library of Science (PLoS), 2019)
    State Visual Evoked Potentials (SSVEPs) arise from a resonance phenomenon in the visual cortex that is produced by a repetitive visual stimulus. SSVEPs have long been considered a steady-state response resulting from purely ...
  • Collective stochastic coherence and synchronizability in weighted scale-free networks
    Balenzuela, Pablo; Rué, Pau; Boccaletti, Stefano; García Ojalvo, Jordi (IOP Publishing, 2014)
    Coupling frequently enhances noise-induced coherence and synchronization in interacting nonlinear systems, but it does so separately. In principle collective stochastic coherence and synchronizability are incompatible ...
  • Comparison between an exact and a heuristic neural mass model with second-order synapses
    Clusella, Pau; Köksal-Ersöz, Elif; García Ojalvo, Jordi; Ruffini, Giulio (Springer, 2022)
    Neural mass models (NMMs) are designed to reproduce the collective dynamics of neuronal populations. A common framework for NMMs assumes heuristically that the output firing rate of a neural population can be described by ...
  • Complex photonics: dynamics and applications of delay-coupled/nsemiconductors lasers
    Soriano, Miguel C.; García Ojalvo, Jordi; Mirasso, Claudio R.; Fischer, Ingo (American Physical Society, 2013)
    Complex phenomena in photonics, in particular, dynamical properties of semiconductor lasers due to delayed coupling, are reviewed. Although considered a nuisance for a long time, these phenomena now open interesting ...
  • Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks
    Clusella, Pau; Deco, Gustavo; Kringelbach, Morten L.; Ruffini, Giulio; García Ojalvo, Jordi (Public Library of Science (PLoS), 2023)
    Spatiotemporal oscillations underlie all cognitive brain functions. Large-scale brain models, constrained by neuroimaging data, aim to trace the principles underlying such macroscopic neural activity from the intricate and ...
  • Computationl and modeling approaches to multi-scale anatomical description of neuronal circuitry
    Manubens-Gil, Linus, 1989- (Universitat Pompeu Fabra, 2018-01-18)
    During the last century the nervous system has been mainly studied from a reductionistic approach, based on the hypothesis that understanding in depth single neurons or limited neuronal populations would lead to general ...
  • Consistency of heterogeneous synchronization patterns in complex weighted networks
    Malagarriga, Daniel; Villa, Alessandro E. P.; García Ojalvo, Jordi; Pons, Antonio J. (American Institute of Physics (AIP), 2017)
    Synchronization within the dynamical nodes of a complex network is usually considered homogeneous through all the nodes. Here we show, in contrast, that subsets of interacting oscillators may synchronize in different ways ...
  • Cross-frequency transfer in a stochastically driven mesoscopic neuronal model
    Jedynak, Maciej; Pons, Antonio J.; García Ojalvo, Jordi (Frontiers, 2015)
    The brain is known to operate in multiple coexisting frequency bands. Increasing experimental evidence suggests that interactions between those distinct bands play a crucial role in brain processes, but the dynamical ...
  • Detection of generalized synchronization using echo state networks
    Ibáñez Soria, David, 1983-; García Ojalvo, Jordi; Soria Frisch, Aureli; Ruffini, G. (American Institute of Physics (AIP), 2018)
    Generalized synchronization between coupled dynamical systems is a phenomenon of relevance in applications that range from secure communications to physiological modelling. Here, we test the capabilities of reservoir ...
  • Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
    Molina Fernández, Rubén; Picón-Pagès, Pol; Barranco Almohalla, Alejandro; Crepin, Giulia; Herrera-Fernández, Víctor; García-Elías, Anna; Fanlo-Ucar, Hugo; Fernàndez Busquets, Xavier; García Ojalvo, Jordi; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Oxford University Press, 2022)
    Alzheimer's disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer's disease and insulin resistance (one of the first ...
  • Differentiating resting brain states using ordinal symbolic analysis
    Quintero-Quiroz, Carlos; Montesano, Luis; Pons, Antonio J.; Torrent, Maria Carme; García Ojalvo, Jordi; Masoller, Cristina (American Institute of Physics (AIP), 2018)
    Symbolic methods of analysis are valuable tools for investigating complex time-dependent signals. In particular, the ordinal method defines sequences of symbols according to the ordering in which values appear in a time ...