Browsing by Author "García, Jesús"

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  • A glutamine-based single α-helix scaffold to target globular proteins
    Escobedo, Albert; Piccirillo, Jonathan; Aranda, Juan; Diercks, Tammo; Mateos, Borja; Garcia-Cabau, Carla; Sánchez-Navarro, Macarena; Topal, Busra; Biesaga, Mateusz; Staby, Lasse; Kragelund, Birthe B.; García, Jesús; Millet, Oscar; Orozco, Modesto; Coles, Murray; Crehuet, Ramon; Salvatella, Xavier (Nature Research, 2022)
    The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules ...
  • Regulation of androgen receptor activity by transient interactions of its transactivation domain with general transcription regulators
    De Mol, Eva; Szulc, Elzbieta; Di Sanza, Claudio; Martínez-Cristóbal, Paula; Bertoncini, Carlos W.; Fenwick, R. Bryn; Frigolé-Vivas, Marta; Masín, Marianela; Hunter, Irene; Buzón, Víctor; Brun-Heath, Isabelle; García, Jesús; De Fabritiis, Gianni; Estébanez-Perpiñá, Eva; McEwan, Iain J.; Nebreda, Ángel R.; Salvatella, Xavier (Elsevier, 2018)
    The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The ...