Browsing by Author "Gallego, Oriol"

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  • Advanced microscopy to resolve the higher-order organization of the exocyst
    Puig Tintó, Marta (Universitat Pompeu Fabra, 2023-05-08)
    The exocyst is an heterooctameric protein complex that tethers secretory vesicles to the plasma membrane during exocytosis. Each exocytic event is mediated by 10-15 exocysts. However, how multiple exocysts organize in time ...
  • CM2D3: furnishing the human interactome with structural models of protein complexes derived by comparative modeling and docking
    Mirela Bota, Patricia; Hernández, Altair C.; Segura, Joan; Gallego, Oriol; Oliva Miguel, Baldomero; Fernández Fuentes, Narcís (Elsevier, 2023)
    The human interactome is composed of around half a million interactions according to recent estimations and it is only for a small fraction of those that three-dimensional structural information is available. Indeed, the ...
  • Live-cell structural biology to solve biological mechanisms: the case of the exocyst
    Irastorza-Azcarate, Ibai; Castaño-Díez, Daniel; Devos, Damien P.; Gallego, Oriol (Elsevier, 2019)
    Historically, structural biology has been largely centered on in vitro approaches as the dominant technique to obtain indispensable high-resolution data. In situ structural biology is now poised to contribute with ...
  • The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
    Pazos, Irene; Puig-Tintó, Marta; Betancur, Laura; Cordero, Jorge; Jiménez-Menéndez, Nereida; Abella, Marc; Hernández, Altair C.; Duran, Ana G.; Adachi-Fernández, Emi; Belmonte Mateos, Carla, 1992-; Sabido-Bozo, Susana; Tosi, Sebastien; Nezu, Akiko; Oliva Miguel, Baldomero; Colombelli, Julien; Graham, Todd R.; Yoshimori, Tamotsu; Muñiz, Manuel; Hamasaki, Maho; Gallego, Oriol (EMBO Press, 2023)
    Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that tether vesicles at the acceptor membrane. Interactions with other components of the trafficking machinery regulate MTCs through mechanisms ...
  • TRAPPIII requires Drs2 binding to transport Atg9 vesicles at cold temperatures
    Puig-Tintó, Marta; Pazos, Irene; Betancur, Laura; Hernández, Altair C.; Gallego, Oriol (Taylor & Francis, 2023)
    Autophagy-related 9 (Atg9); cytoplasm-to-vacuole targeting (Cvt); Golgi-associated retrograde protein (GARP); multisubunit tethering complexes (MTCs); phagophore assembly site (PAS); phosphatidylserine (PS); Protein ...