Browsing by Author "Felipe, Antonio"

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  • Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences
    Villalonga, Núria; David, Miren; Bielanska, Joanna; Vicente García, Rubén, 1978-; Comes, Núria; Valenzuela, Carmen; Felipe, Antonio (Rockefeller University Press, 2010)
    Voltage-dependent potassium (K(v)) channels play a pivotal role in the modulation of macrophage physiology. Macrophages are professional antigen-presenting cells and produce inflammatory and immunoactive substances that ...
  • Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia
    Coma Camprodón, Mireia; Vicente García, Rubén, 1978-; Busquets, Silvia; Carbó, Neus; Tamkun, Michael M.; López Soriano, Francisco J.; Argilés, Josep M.; Felipe, Antonio (Elsevier, 2003)
    Cancer-induced cachexia affects most advanced cancer patients. It is characterized by anorexia, profound metabolic dysfunctions, and severe neurological disorders. Here we show that voltage-gated potassium channel (Kv) ...
  • KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating
    Solé, Laura; Roura Ferrer, Meritxell; Pérez Verdaguer, Mireia; Oliveras, Anna; Calvo, Maria; Fernández-Fernández, José Manuel, 1967-; Felipe, Antonio (Company of Biologists, 2009)
    Voltage-dependent potassium channels (Kv) play a crucial role in the activation and proliferation of leukocytes. Kv channels are either homo- or hetero-oligomers. This composition modulates their surface expression and ...
  • Multiple Kv1.5 targeting to membrane surface microdomains
    Martínez-Mármol, Ramón; Villalonga, Núria; Solé, Laura; Vicente García, Rubén, 1978-; Tamkun, Michael M.; Soler, Concepció; Felipe, Antonio (Wiley-VCH Verlag, 2008)
    Surface expression of voltage-dependent K(+) channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules ...
  • The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways
    Vicente García, Rubén, 1978-; Coma Camprodón, Mireia; Busquets, Silvia; Moore Carrasco, Rodrigo; López Soriano, Francisco J.; Argilés, Josep M.; Felipe, Antonio (Elsevier, 2004)
    TNF-alpha, generated during the systemic inflammatory response, triggers a wide range of biological activities that mediate the neurologic manifestations associated with cancer and infection. Since this cytokine regulates ...
  • Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis
    Martínez-Mármol, Ramón; Comes, Núria; Styrczewska, Katarzyna; Pérez Verdaguer, Mireia; Vicente García, Rubén, 1978-; Pujadas, Lluís; Soriano, Eduardo; Sorkin, Alexander; Felipe, Antonio (Springer, 2016)
    The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and ...