Browsing by Author "Elosua Llanos, Roberto"

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  • Rodrigo, Emilio; Pich, Sara; Subirana Cachinero, Isaac; Fernandez-Fresnedo, Gema; Barreda, Paloma; Ferrer-Costa, Carles; de Francisco, Angel Luis M.; Salas, Eduardo; Elosua Llanos, Roberto; Arias, Manuel (Oxford University Press, 2017)
    BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported ...
  • Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)
    BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
  • Musameh, Muntaser D.; Wang, William Y. S.; Nelson, Christopher P.; Lluís Ganella, Carla, 1984-; Debiec, Radoslaw; Subirana Cachinero, Isaac; Elosua Llanos, Roberto; Balmforth, Anthony J.; Ball, Stephen G.; Hall, Alistair S.; Kathiresan, Sekar; Thompson, John R.; Lucas, Gavin, 1977-; Samani, Nilesh J.; Tomaszewski, Maciej (Public Library of Science, 2015)
    OBJECTIVE: Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for ...
  • Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (Nature Research, 2018)
    Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted ...
  • Lek, Monkol; Elosua Llanos, Roberto; MacArthur, Daniel G.; Exome Aggregation Consortium (Macmillan Publishers, 2016)
    Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding ...
  • Gimeno Vázquez, Eva; Subirana Cachinero, Isaac; Gómez Pérez, Miguel Angel; Díaz, Javier; Sanchez Gonzalez, Blanca; García-Pallarols, Francesc; Martínez, Laia; Ble, Mireia; Molina Ferragut, Luis; Belarte Tornero, Laia Carla; Abella Monreal, Eugenia; Elosua Llanos, Roberto; Comín Colet, Josep; Salar Silvestre, Antonio (Wiley, 2019)
    OBJECTIVE: To evaluate the role of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and a cardiovascular (CV) risk score named FRESCO for predicting anthracycline-induced cardiotoxicity (AIC) in diffuse large ...
  • Baena Díez, Jose M.; Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Prieto-Alhambra, Daniel; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Peñafiel Muñoz, Judith; Grau Magaña, Maria (BMJ Publishing Group, 2017)
  • Fernández Sanlés, Alba; Sayols, Sergi; Subirana Cachinero, Isaac; Dégano, Irene R.; Elosua Llanos, Roberto (Elsevier, 2017)
    BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was ...
  • Sayols, Sergi; Fernández Sanlés, Alba; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)
    INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
  • Rivera, Marcela, 1982-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Foraster Pulido, Maria, 1984-; Agis, David; Groot, Eric de; Pérez Grau, Laura; Mendez, Michelle A.; Bouso, Laura; Targa, Jaume; Ramos, Rafel; Sala, Joan; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2013)
    BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related ...
  • Marini, Sandro; Roquer, Jaume; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Elosua Llanos, Roberto; Cuadrado Godia, Elisa; Soriano Tarraga, Carolina; Anderson, Christopher D.; International Stroke Genetics Consortium (American Medical Association, 2019)
    Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic ...
  • Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)
    Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
  • Schröder, Helmut, 1958-; Serra-Majem, Luis; Subirana Cachinero, Isaac; Izquierdo Pulido, Maria; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Cambridge University Press, 2016)
    Higher monetary diet cost is associated with healthier food choices and better weight management. How changes in diet cost affect changes in diet quality and weight remains unknown. The aim of this study was to assess the ...
  • Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Rivera, Marcela, 1982-; Agis, David; Bouso, Laura; Deltell, Alexandre; Marrugat de la Iglesia, Jaume; Ramos, Rafel; Sunyer Deu, Jordi; Vila, Joan; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure ...
  • Serra, Guillem; Baranchuk, Adrian; Bayés-De-Luna, Antoni; Brugada, Josep; Goldwasser, Diego; Capulzini, Lucio; Arazo, David; Boraita, Araceli; Heras, Maria-Eugenia; Garcia-Niebla, Javier; Elosua Llanos, Roberto; Brugada, Ramón; Brugada, Pedro (Oxford University Press, 2015)
  • Elosua Llanos, Roberto; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin, 1977-; Sayols, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí Clapés, Mariano; Siscovick, David; Mellander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat de la Iglesia, Jaume (Lippincott Williams & Wilkins, 2016)
    BACKGROUND: Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk ...
  • Fernández Sanlés, Alba (Universitat Pompeu Fabra, 2020-01-31)
    Cardiovascular diseases are a major challenge for public health. DNA methylation is a mechanism regulating gene expression, and it is linked to complex diseases and related traits. Therefore, it is a potential source of ...
  • Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (American Diabetes Association, 2019)
    A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of ...
  • Fa-Binefa, Manel; Clarà Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)
    Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
  • Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Martí, Ruth; Alves-Cabratosa, Lia; Parramon, Dídac; Prieto-Alhambra, Daniel; Baena Díez, Jose M.; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Marrugat de la Iglesia, Jaume; Grau Magaña, Maria (SAGE Publications, 2019)
    Background: Cardiovascular guidelines do not give firm recommendations on statin therapy in patients with gout because evidence is lacking. Aim: To analyze the effectiveness of statin therapy in primary prevention of ...