Casas, Ana I.; Hassan, Ahmed; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; López, Manuela G.; Baumbach, Jan; Schmidt, Harald H.H.W.
(National Academy of Sciences, 2019)
Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rather than mechanistic approaches have contributed. We here explore a mechanism-based disease definition for network ...