Browsing by Author "Curwin, Amy"

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  • ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1
    Blume, Julia von; Alleaume, Anne-Marie; Cantero Recasens, Gerard, 1984-; Curwin, Amy; Carreras Sureda, Amado, 1986-; Zimmermann, Timo; Galen, Josse van; Wakana, Yuichi; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Elsevier, 2011)
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells. How do these cytoplasmic proteins interact with the cargoes in the lumen of the TGN? ...
  • Cofilin-mediated sorting and export of specific cargo from the Golgi apparatus in yeast
    Curwin, Amy; Blume, Julia von; Malhotra, Vivek (American Society for Cell Biology, 2012)
    The mechanism of cargo sorting at the trans-Golgi network (TGN) for secretion is poorly understood. We previously reported the involvement of the actin-severing protein cofilin and the Ca(2+) ATPase secretory pathway calcium ...
  • ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
    Curwin, Amy; Brouwers, Nathalie; Alonso Y Adell, Manuel; Teis, David; Turacchio, Gabriele; Parashuraman, Seetharaman; Ronchi, Paolo; Malhotra, Vivek (eLife, 2016)
    The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment ...
  • Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1
    Cruz Garcia, David; Brouwers, Nathalie; Malhotra, Vivek; Curwin, Amy (Rockefeller University Press, 2020)
    Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other ...