Browsing by Author "Cosma, Maria Pia, 1970-"

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  • Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development
    Frade, João; Nakagawa, Shoma; Cortes, Paola; Di Vicino, Umberto; Romo Saladrigas, Neus, 1982-; Lluis Vinas, Frederic; Cosma, Maria Pia, 1970- (American Association for the Advancement of Science (AAAS), 2019)
    Cells with high ploidy content are common in mammalian extraembryonic and adult tissues. Cell-to-cell fusion generates polyploid cells during mammalian development and tissue regeneration. However, whether increased ploidy ...
  • Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis
    Sottile, Francesco, 1988-; Aulicino, Francesco, 1987-; Theka, Ilda, 1984-; Cosma, Maria Pia, 1970- (Nature Publishing Group, 2016)
    Homotypic and heterotypic cell-to-cell fusion are key processes during development and tissue regeneration. Nevertheless, aberrant cell fusion can contribute to tumour initiation and metastasis. Additionally, a form of ...
  • Modeling dynamics and function of bone marrow cells in mouse liver regeneration
    Pedone, Elisa, 1985-; Olteanu, Vlad Aris; Marucci, Lucia; Muñoz-Martin, Maria Isabel; Youssef, Sameh A.; de Bruin, Alain; Cosma, Maria Pia, 1970- (Elsevier, 2017)
    In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate ...
  • (Po)STAC (Polycistronic SunTAg modified CRISPR) enables live-cell and fixed-cell super-resolution imaging of multiple genes
    Neguembor, Maria Victoria; Sebastián Pérez, Rubén; Aulicino, Francesco, 1987-; Gómez García, Pablo; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Oxford University Press, 2018)
    CRISPR/dCas9-based labeling has allowed direct visualization of genomic regions in living cells. However, poor labeling efficiency and signal-to-background ratio have limited its application to visualize genome organization ...
  • Super resolution imaging of chromatin in pluripotency, differentiation, and reprogramming
    Ricci, Maria Aurelia, 1985-; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Elsevier, 2017)
    Chromatin fiber organization is essential for gene function in all cell types. Moreover it helps to determine cell fate in embryonic/adult stem cells and in somatic cells undergoing reprogramming to pluripotency. Until now ...
  • Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo
    Otterstrom, Jason; Castells García, Àlvaro, 1991-; Vicario, Chiara; Gómez García, Pablo; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Oxford University Press, 2019)
    Chromatin organization is crucial for regulating gene expression. Previously, we showed that nucleosomes form groups, termed clutches. Clutch size correlated with the pluripotency grade of mouse embryonic stem cells and ...
  • The master regulator protein BAZ2B can reprogram human hematopoietic lineage-committed progenitors into a multipotent state
    Arumugam, Karthik; Shin, William; Schiavone, Valentina; Vlahos, Lukas; Tu, Xiaochuan; Carnevali, Davide; Kesner, Jordan; Paull, Evan O.; Romo Saladrigas, Neus, 1982-; Subramanian, Prem; Worley, Jeremy; Tan, Xiangtian; Califano, Andrea; Cosma, Maria Pia, 1970- (Science Direct, 2020)
    Bi-species, fusion-mediated, somatic cell reprogramming allows precise, organism-specific tracking of unknown lineage drivers. The fusion of Tcf7l1-/- murine embryonic stem cells with EBV-transformed human B cell lymphocytes, ...
  • The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
    Ritschka, Birgit,1985-; Knauer-Meyer, Tania; Sampaio Gonçalves, Daniel; Mas, Alba; Plassat, Jean-Luc; Durik, Matej; Jacobs, Hugues; Pedone, Elisa, 1985-; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that ...
  • The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency
    Athanasouli, Paraskevi; Balli, Martina; De Jaime-Soguero, Anchel; Boel, Annekatrien; Papanikolaou, Sofia; van der Veer, Bernard K.; Janiszewski, Adrian; Vanhessche, Tijs; Francis, Annick; El Laithy, Youssef; Lo Nigro, Antonio; Aulicino, Francesco, 1987-; Koh, Kian Peng; Pasque, Vincent; Cosma, Maria Pia, 1970-; Verfaillie, Catherine; Zwijsen, An; Heindryckx, Björn; Nikolaou, Christoforos; Lluis Vinas, Frederic (Nature Research, 2023)
    Early during preimplantation development and in heterogeneous mouse embryonic stem cells (mESC) culture, pluripotent cells are specified towards either the primed epiblast or the primitive endoderm (PE) lineage. Canonical ...
  • Transcription-mediated supercoiling regulates genome folding and loop formation
    Neguembor, Maria Victoria; Martin, Laura; Castells García, Àlvaro, 1991-; Gómez García, Pablo; Vicario, Chiara; Carnevali, Davide; Abed, Jumana AlHaj; Granados, Alba; Sebastián Pérez, Rubén; Sottile, Francesco, 1988-; Solon, Jérôme; Wu, Chao-Ting; Lakadamyali, Melike; Cosma, Maria Pia, 1970- (Elsevier, 2021)
    The chromatin fiber folds into loops, but the mechanisms controlling loop extrusion are still poorly understood. Using super-resolution microscopy, we visualize that loops in intact nuclei are formed by a scaffold of cohesin ...
  • Visualizing the genome in high resolution challenges our textbook understanding
    Lakadamyali, Melike; Cosma, Maria Pia, 1970- (Nature Research, 2020)
    The relationship between the 4D folding of the genome and its function is an outstanding question in biology. A range of methods that probe the folding of the genome in space and time with unprecedented resolution have ...
  • Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus
    de Jaime Soguero, Anchel; Aulicino, Francesco, 1987-; Ertaylan, Gokhan; Griego, Anna; Cerrato, Aniello; Tallam, Aravind; del Sol, Antonio; Cosma, Maria Pia, 1970-; Lluis Vinas, Frederic (Public Library of Science (PLoS), 2017)
    Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. ...
  • Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
    Theka, Ilda, 1984-; Sottile, Francesco, 1988-; Cammisa, Marco; Bonnin, Sarah; Sanchez-Delgado, Marta; Di Vicino, Umberto; Neguembor, Maria Victoria; Arumugam, Karthik; Aulicino, Francesco, 1987-; Monk, David; Riccio, Andrea; Cosma, Maria Pia, 1970- (Nature Research, 2019)
    Mouse embryonic stem cells (mESCs) are pluripotent and can differentiate into cells belonging to the three germ layers of the embryo. However, mESC pluripotency and genome stability can be compromised in prolonged in vitro ...
  • Women's contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization
    Martin, Laura; Neguembor, Maria Victoria; Cosma, Maria Pia, 1970- (Frontiers, 2023)
    One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller. To fit into the nucleus, DNA twists, bends and folds into several ...
  • β-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated/nreprogramming of somatic cells to pluripotency
    Marucci, Lucia; Pedone, Elisa, 1985-; Vicino, Umberto di; Sanuy-Escribano, Blanca; Isalan, Mark; Cosma, Maria Pia, 1970- (Elsevier, 2014)
    The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to ...
  • β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus
    Zhang, Meng; Arumugam, Karthik; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Esteban, Miguel A. (American Association for the Advancement of Science (AAAS), 2020)
    Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3) inhibitors (2i) more closely resemble the inner cell mass of preimplantation blastocysts than ...

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