Visualitza per autoria "Colomer Montañà, Carlota, 1990-"

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  • A novel role of MNT as a negative regulator of REL and the NF-κB pathway
    Liaño-Pons, Judit; Lafita-Navarro, M. Carmen; García-Gaipo, Lorena; Colomer Montañà, Carlota, 1990-; Rodríguez, Javier; von Kriegsheim, Alex; Hurlin, Peter J.; Ourique, Fabiana; Delgado, M. Dolores; Bigas Salvans, Anna; Espinosa Blay, Lluís; León, Javier (Nature Research, 2021)
    MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix-loop-helix proteins that heterodimerize with MAX in a mutually exclusive manner, and bind ...
  • BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent
    Margalef González, Pol, 1985-; Colomer Montañà, Carlota, 1990-; Villanueva, Alberto; Montagut Viladot, Clara; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Salazar, Ramón; Martínez Iniesta, María; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Association for the Advancement of Science, 2015)
    KRAS mutations contribute to cell proliferation and survival in numerous cancers, including colorectal cancers (CRC). One pathway through which mutant KRAS acts is an inflammatory pathway that involves the kinase IKK and ...
  • IKKα is required in the intestinal epithelial cells for tumour stemness
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; González, Jessica; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
    BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. ...
  • IKKα kinase regulates the DNA damage response and drives chemo-resistance in cancer
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; Villanueva, Alberto; Vert, Anna; Pecharroman, Irene; Solé, Laura; González-Farré, Mónica; Alonso, Josune; Montagut Viladot, Clara; Martínez Iniesta, María; Bertran, Joan; Borràs, Eva; Iglesias, Mar; Sabidó Aguadé, Eduard, 1981-; Bigas Salvans, Anna; Boulton, Simon J.; Espinosa Blay, Lluís (Elsevier, 2019)
    Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-¿B signaling. Insights into the sources ...
  • Manic fringe deficiency imposes jagged1 addiction to intestinal tumor cells
    López Arribillaga, Erika, 1986-; Rodilla, Verónica; Colomer Montañà, Carlota, 1990-; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)
    Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
  • NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
    Colomer Montañà, Carlota, 1990-; Marruecos, Laura; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (MDPI, 2017)
    Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent ...
  • SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway
    Santos-Barriopedro, Irene; Bosch-Presegué, Laia; Marazuela-Duque, Anna; Torre, Carolina de la; Colomer Montañà, Carlota, 1990-; Vázquez, Berta N.; Fuhrmann, Thomas; Martínez-Pastor, Bárbara; Lu, Wenfu; Braun, Thomas; Bober, Eva; Jenuwein, Thomas; Serrano, Lourdes; Esteller, Manel; Chen, Zhenbang; Barceló-Batllori, Silvia; Mostoslavsky, Raúl; Espinosa Blay, Lluís; Vaquero, Alejandro (Nature Publishing Group, 2018)
    Sirtuins are NAD+-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an ...

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