Browsing by Author "Castellano Hereza, Sergi"

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  • Ancient gene flow from early modern humans into Eastern Neanderthals
    Kuhlwilm, Martin; Prado Martínez, Javier, 1987-; Lalueza Fox, Carles, 1965-; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi (Nature Research, 2016)
    It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together ...
  • Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?
    Taskov, Kalin; Chapple, Charles E.; Kryukov, Gregory V.; Castellano Hereza, Sergi; Lobanov, Alexei V.; Korotkov, Konstantin V.; Guigó Serra, Roderic; Gladyshev, Vadim N. (Oxford University Press, 2005)
    Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS) element. The number of selenoproteins in animals varies, with ...
  • SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements
    Castellano Hereza, Sergi; Gladyshev, Vadim N.; Guigó Serra, Roderic; Berry, Marla J. (Oxford University Press, 2008)
    Selenoproteins are a diverse group of proteins/nusually misidentified and misannotated in sequence/ndatabases. The presence of an in-frame UGA (stop)/ncodon in the coding sequence of selenoprotein/ngenes precludes their ...
  • SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans
    Romagné, Frédéric; Santesmasses Ruiz, Didac, 1978-; White, Louise; Sarangi, Gaurab K.; Mariotti, Marco, 1984-; Hübler, Ron; Weihmann, Antje; Parra Farré, Genís; Gladyshev, Vadim N.; Guigó Serra, Roderic; Castellano Hereza, Sergi (Oxford University Press, 2014)
    SelenoDB (http://www.selenodb.org) aims to provide high-quality annotations of selenoprotein genes, proteins and SECIS elements. Selenoproteins are proteins that contain the amino acid selenocysteine (Sec) and the first ...
  • The impact of genetic adaptation on chimpanzee subspecies differentiation
    Schmidt, Joshua M.; de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi; Andrés Morán, Aida, 1976- (Public Library of Science (PLoS), 2019)
    Chimpanzees, humans' closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their ...
  • Towards the characterization of the eukaryotic selenoproteome: a computational approach
    Castellano Hereza, Sergi (Universitat Pompeu Fabra, 2011-04-12)
    Although the genome sequence and gene content are available for an increasing number of organisms, eukaryotic selenoproteins remain poorly characterized. In these proteins, selenium (Se) is incorporated in the form of ...

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