Browsing by Author "Bustelo, Xose R."

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  • Robles-Valero, Javier; Lorenzo-Martín, L. Francisco; Menacho Márquez, Mauricio; Fernández-Pisonero, Isabel; Abad, Antonio; Camós, Mireia; Toribio, María Luisa; Espinosa Blay, Lluís; Bigas Salvans, Anna; Bustelo, Xose R. (Elsevier, 2017)
    Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their ...
  • Robles-Valero, Javier; Fernández-Nevado, Lucía; Cuadrado, Myriam; Lorenzo-Martín, L. Francisco; Fernández-Pisonero, Isabel; Abad, Antonio; Redín, Esther; Montuenga, Luis; Martín-Zanca, Dionisio; Bigas Salvans, Anna; Mallo, Moises; Dosil, Mercedes; Bustelo, Xose R. (Wiley, 2022)
    Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall-cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene-edited ...

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