Browsing by Author "Bolognesi, Benedetta"

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  • Bolognesi, Benedetta; Lorenzo Gotor, Maria de las Nieves; Dhar, Riddhiman; Cirillo, Davide; Baldrighi, Marta; Gaetano Tartaglia, Gian; Lehner, Ben, 1978- (Elsevier, 2016)
    Multiple human diseases are associated with a liquid-to-solid phase transition resulting in the formation of amyloid fibers or protein aggregates. Here, we present an alternative mechanism for cellular toxicity based on a ...
  • Cid-Samper, Fernando; Gelabert-Baldrich, Mariona; Lang, Benjamin; Lorenzo Gotor, Maria de las Nieves; Ponti, Riccardo delli; Severijnen, Lies-Anne W.F.M.; Bolognesi, Benedetta; Gelpi, Ellen; Hukema, Renate K.; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Elsevier, 2018)
    Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein condensates by acting as scaffolds for RNA-binding proteins (RBPs). We systematically investigated RNA-RBP interaction networks to ...
  • Riemschoss, Katrin; Arndt, Verena; Bolognesi, Benedetta; von Eisenhart-Rothe, Philipp; Liu, Shu; Buravlova, Oleksandra; Duernberger, Yvonne; Paulsen, Lydia; Hornberger, Annika; Hossinger, André; Lorenzo Gotor, Maria de las Nieves; Hogl, Sebastian; Müller, Stephan A.; Tartaglia, Gian Gaetano; Lichtenthaler, Stefan F.; Vorberg, Ina M. (Life Science Alliance, 2019)
    Prions of lower eukaryotes are self-templating protein aggregates that replicate by converting homotypic proteins into stable, tightly packed beta-sheet-rich protein assemblies. Propagation is mediated by prion domains, ...
  • Cirillo, Davide; Agostini, Federico, 1985-; Klus, Petr, 1985-; Marchese, Domenica, 1986-; Rodríguez, Silvia; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. ...
  • Zanzoni, Andreas; Marchese, Domenica, 1986-; Agostini, Federico, 1985-; Bolognesi, Benedetta; Cirillo, Davide; Botta-Orfila, Maria; Livi, Carmen Maria; Rodriguez-Mulero, Silvia; Tartaglia, Gian Gaetano (Oxford University Press, 2013)
    Previous evidence indicates that a number of proteins are able to interact with cognate mRNAs. These autogenous associations represent important regulatory mechanisms that control gene expression at the translational level. ...
  • Porcari, Riccardo; Proukakis, Christos; Waudby, Christopher A.; Bolognesi, Benedetta; Mangione, P. Patrizia; Paton, Jack F. S.; Mullin, Stephen; Cabrita, Lisa D.; Penco, Amanda; Relini, Annalisa; Verona, Guglielmo; Vendruscolo, Michele; Stoppini, Monica; Tartaglia, Gian Gaetano; Camilloni, Carlo; Christodoulou, John; Schapira, Anthony H. V.; Bellotti, Vittorio (American Society for Biochemistry and Molecular Biology, 2015)
    The conversion of α-synuclein from its intrinsically disordered monomeric state into the fibrillar cross-β aggregates characteristically present in Lewy bodies is largely unknown. The investigation of α-synuclein variants ...
  • Bolognesi, Benedetta; Faure, Andre J.; Seuma, Mireia; Schmiedel, Jörn M.; Tartaglia, Gian Gaetano; Lehner, Ben, 1978- (Nature Research, 2019)
    Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause ...
  • Agostini, Federico, 1985-; Cirillo, Davide; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Oxford University Press, 2013)
    The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of ...