Browsing by Author "Barkhof, Frederik"

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  • Sala Vila, Aleix; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Grau-Rivera, Oriol; González de Echávarri, José Maria; Crous-Bou, Marta; Minguillón, Carolina; Fauria, Karine; Operto, Grégory; Falcón, Carles; Salvadó, Gemma; Cacciaglia, Raffaele; Ingala, Silvia; Barkhof, Frederik; Schröder, Helmut, 1958-; Scarmeas, Nikolaos; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (American Society for Nutrition, 2021)
    Background: The number of APOE-ε4 alleles is a major nonmodifiable risk factor for sporadic Alzheimer disease (AD). There is increasing evidence on the benefits of dietary DHA (22:6n-3) before the onset of AD symptoms, ...
  • Heeman, Fiona; Yaqub, Maqsood; Hendriks, Janine; van Berckel, Bart N. M.; Collij, Lyduine E.; Gray, Katherine R.; Manber, Richard; Wolz, Robin; Garibotto, Valentina; Wimberley, Catriona; Ritchie, Craig; Barkhof, Frederik; Gispert López, Juan Domingo; Vállez García, David; Lopes Alves, Isadora; Lammertsma, Adriaan A.; AMYPAD Consortium (SpringerOpen, 2022)
    Background: despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in ...
  • Heeman, Fiona; Yaqub, Maqsood; Hendriks, Janine; Bader, Ilona; Barkhof, Frederik; Gispert López, Juan Domingo; van Berckel, Bart N. M.; Lopes Alves, Isadora; Lammertsma, Adriaan A. (Elsevier, 2021)
    Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18F]flutemetamol and [18F]florbetaben scans have previously been identified at a region of interest (ROI) level. The purpose of this study ...
  • Brugulat Serrat, Anna, 1986-; Salvadó, Gemma; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Springer, 2019)
    White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and ...
  • Collij, Lyduine E.; Salvadó, Gemma; de Wilde, Arno; Altomare, Daniele; Shekari, Mahnaz; Domingo Gispert, Juan; Bullich, Santiago; Stephens, Andrew W.; Barkhof, Frederik; Scheltens, Philip; Bouwman, Femke; van der Flier, Wiesje M. (Wiley, 2022)
    Introduction: we investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18 F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified ...
  • Pemberton, Hugh G.; Collij, Lyduine E.; Heeman, Fiona; Bollack, Ariane; Shekari, Mahnaz; Salvadó, Gemma; Lopes Alves, Isadora; Vallez Garcia, David; Battle, Mark; Buckley, Christopher, 1948-; Stephens, Andrew W.; Bullich, Santiago; Garibotto, Valentina; Barkhof, Frederik; Gispert López, Juan Domingo; Farrar, Gill; AMYPAD Consortium (Springer, 2022)
    Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be determined in vivo using positron emission ...
  • Collij, Lyduine E.; Mastenbroek, Sophie E.; Salvadó, Gemma; Wink, Alle Meije; Visser, Pieter Jelle; Barkhof, Frederik; van Berckel, Bart N. M.; Lopes Alves, Isadora (Elsevier, 2021)
    Introduction: The value of quantitative longitudinal and regional amyloid beta (Aβ) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined. Methods: We ...
  • Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)
    Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
  • Collij, Lyduine E.; Salvadó, Gemma; Wottschel, Viktor; Mastenbroek, Sophie E.; Schoenmakers, Pierre; Heeman, Fiona; Aksman, Leon; Wink, Alle Meije; Berckel, Bart N.M.; van de Flier, Wiesje M.; Scheltens, Philip; Visser, Pieter Jelle; Barkhof, Frederik; Haller, Sven; Gispert López, Juan Domingo; Lopes Alves, Isadora; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage ...
  • Lopes Alves, Isadora; Heeman, Fiona; Collij, Lyduine E.; Salvadó, Gemma; Tolboom, Nelleke; Vilor Tejedor, Natàlia, 1988-; Markiewicz, Pawel; Yaqub, Maqsood; Cash, David; Mormino, Elizabeth C.; Insel, Philip S.; Boellaard, Ronald; van Berckel, Bart N. M.; Lammertsma, Adriaan A.; Barkhof, Frederik; Gispert López, Juan Domingo (BioMed Central, 2021)
    Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer's disease (AD). This work aimed ...
  • Markiewicz, Pawel J.; Gispert López, Juan Domingo; Barkhof, Frederik (Elsevier, 2021)
    Accurate regional brain quantitative PET measurements, particularly when using partial volume correction, rely on robust image registration between PET and MR images. We argue here that the precision, and hence the ...
  • Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle-Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...
  • Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)
    White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...

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