Browsing by Author "Aguirre Plans, Joaquim, 1993-"

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  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Souza, Terezinha; Callegaro, Giulia; Kunnen, Steven J.; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Guney, Emre; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim, 1993-; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)
    The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
  • Artigas, Laura; Coma Camprodón, Mireia; Matos Filipe, Pedro; Aguirre Plans, Joaquim, 1993-; Farrés, Judith; Valls, Raquel; Fernández Fuentes, Narcís; Haba Rodríguez, Juan de la; Olvera, Alex; Barbera, Jose; Morales, Rafael; Oliva Miguel, Baldomero; Mas, José Manuel (Public Library of Science (PLoS), 2020)
    From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that in some cases can be complicated by the severe acute respiratory syndrome, sepsis and septic shock, ...
  • Jorba Argemí, Guillem; Aguirre Plans, Joaquim, 1993-; Junet, Valentin; Segú-Vergés, Cristina; Ruiz, José Luis; Pujol, Albert; Fernández Fuentes, Narcís; Mas, José Manuel; Oliva Miguel, Baldomero (Public Library of Science (PLoS), 2020)
    Unveiling the mechanism of action of a drug is key to understand the benefits and adverse reactions of a medication in an organism. However, in complex diseases such as heart diseases there is not a unique mechanism of ...
  • Piñero González, Janet, 1977-; Gonzalez-Perez, Abel; Guney, Emre; Aguirre Plans, Joaquim, 1993-; Sanz, Ferran; Oliva Miguel, Baldomero; Furlong, Laura I., 1971- (Frontiers, 2018)
    Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The ...
  • Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Aguirre Plans, Joaquim, 1993-; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (Oxford University Press, 2018)
    MOTIVATION: The characterization of the protein-protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Menche, Jörg; Sanz, Ferran; Furlong, Laura I., 1971-; Schmidt, Harald H.H.W.; Oliva Miguel, Baldomero; Guney, Emre (MDPI, 2018)
    The past decades have witnessed a paradigm shift from the traditional drug discovery shaped around the idea of “one target, one disease” to polypharmacology (multiple targets, one disease). Given the lack of ...
  • Aguirre Plans, Joaquim, 1993-; Meseguer, Alberto; Molina Fernández, Rubén; Marín López, Manuel Alejandro, 1987-; Jumde, Gaurav; Casanova, Kevin; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Statistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) ...

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