Browsing by Author "Abia, David"

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  • A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
    Bovolenta, Elena R.; García-Cuesta, Eva M.; Horndler, Lydia; Ponomarenko, Julia; Schamel, Wolfgang W.; Mellado, Mario; Castro, Mario; Abia, David; van Santen, Hisse M. (National Academy of Sciences, 2022)
    Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and negative selection, lineage ...
  • RRAS2 shapes the TCR repertoire by setting the threshold for negative selection
    Martínez-Riaño, Ana; Bovolenta, Elena R.; Boccasavia, Viola L.; Ponomarenko, Julia; Abia, David; Oeste, Clara L.; Fresno, Manuel; van Santen, Hisse M.; Alarcon, Balbino (Rockefeller University Press, 2019)
    Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the ...
  • Structure and non-structure of centrosomal proteins
    Dos Santos, Helena G.; Abia, David; Janowski, Robert; Mortuza, Gulnahar; Bertero, Michela G.; Boutin, Maïlys; Guarín, Nayibe; Méndez Giraldez, Raúl; Nuñez, Alfonso; Pedrero, Juan G.; Redondo, Pilar; Sanz, María; Speroni, Silvia; Teichert, Florian; Bruix, Maria; Carazo, José M.; González, Cayetano; Reina, José; Valpuesta, José M.; Vernos, Isabelle, 1959-; Zabala, Juan C.; Montoya, Guillermo; Coll, Miquel; Bastolla, Ugo; Serrano Pubull, Luis, 1982- (Public Library of Science (PLoS), 2013)
    Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend to be larger than generic human proteins (control set), since ...

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