• Neuroplasticity-targeted therapy for Down syndrome: a translational approach

  Catuara Solarz, Silvina, 1986- (Universitat Pompeu Fabra, 2016-09-16)

  This Thesis aims at addressing the therapeutic potential of a neuroplasticity-targeted treatment for intellectual disability (ID) in Down syndrome (DS). The therapy consisted of the administration of the green tea catechin ...
• Mesenchymal stem cells generate distinc functional hybrids via cell fusion or entosis

  Sottile, Francesco, 1988- (Universitat Pompeu Fabra, 2017-01-18)

  Homotypic and heterotypic cell-cell fusion are key processes during development and tissue regeneration. On the other hand, aberrant heterotypic cell fusion between cancer and normal cells can contribute to tumor initiation ...
• Evolutionary analysis of the genome load of loss-of-function variants and their contribution to immunodeficiencies

  Valles Ibáñez, Guillem de, 1986- (Universitat Pompeu Fabra, 2016-11-16)

  Human genomes have been found to harbor an unexpected number of ~100 loss-of-function (LoF) variants, with ~20 of them in an homozygous state, in most cases without a visible effect despite its potential truncation of ...
• NGS applications in genome evolution and adaptation : A reproducible approach to NGS data analysis and integration

  Prieto Barja, Pablo, 1986- (Universitat Pompeu Fabra, 2017-01-12)

  In this PhD I have used NGS technologies in different organisms and scenarios such as in ENCODE, comparing the conservation and evolution of long non-coding RNA sequences between human and mouse, using experimental evidences ...
• On contractile actomyosin waves and their role in junctional remodeling during epithelial constriction

  Sumi, Angughali Aheto, 1986- (Universitat Pompeu Fabra, 2017-01-13)

  Epithelial tissues undergo extensive remodeling during embryonic development. Recent studies have revealed that, in a number of developmental processes, epithelial remodeling is associated with pulsations of individual ...

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