García de Herreros, Antonio2024-10-172024García de Herreros A. Dual role of Snail1 as transcriptional repressor and activator. Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189037. DOI: 10.1016/j.bbcan.2023.1890371879-2561http://hdl.handle.net/10230/61507Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a transcriptional repressor and, as growing evidences have demonstrated, also as a direct activator of mesenchymal genes. In this review, I describe the different proteins that interact with Snail1 and are responsible for these two different functions on gene expression; I focus on the transcriptional factors that associate to Snail1 in their target promoters, both activated and repressed. I also present working models for Snail1 action both as repressor and activator and raise some issues that still need to be investigated.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.bbcan.2023.189037info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbcan.2023.189037EMTGene activationGene repressionSnail1info:eu-repo/semantics/embargoedAccess