Zimmer, AndreasValjent, EmmanuelKönig, MonikaZimmer, Anne M.Robledo, Patricia, 1958-Hahn, HeidiValverde Granados, OlgaMaldonado, Rafael, 1961-2012-07-052012-07-052001Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H et al. Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J Neurosci. 2001;21(23):9499-505. DOI: 10.1523/jneurosci.21-23-09499.20010270-6474http://hdl.handle.net/10230/16667The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.application/pdfeng© 2001, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/21/23/9499Cannabinoides -- Efectes fisiològicsCannabinoides -- Receptorsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1523/jneurosci.21-23-09499.2001CannabinoidOpioidMiceMutationWithdrawalAddictionPlace aversioninfo:eu-repo/semantics/openAccess