Soldevila-Domenech, NataliaForcano, LauraBoronat Rigol, Anna, 1990-Lorenzo, ThaisPiera, IrisPuig Pijoan, AlbertMateus Rodriguez, Julian AndrésGonzález de Echávarri, José MariaKnezevic, IvaSoteras, AnnaFauria, KarinePizarro Lozano, Mª NievesMolinuevo, José LuisTorre Fornell, Rafael de laPENSA Study Group2021-03-102021-03-102021Soldevila-Domenech N, Forcano L, Boronat A, Lorenzo T, Piera I, Puig-Pijoan A, Mateus J, González de Echevarri Gómez JM, Knezevic I, Soteras A, Fauria K, Pizarro N, Molinuevo JL, de la Torre R; PENSA Study Group. Effects of COVID-19 home confinement on mental health in individuals with increased risk of Alzheimer's disease. J Alzheimers Dis. 2021; 79(3):1015-21. DOI: 10.3233/JAD-2014081387-2877http://hdl.handle.net/10230/46709We explored the impact of the Spanish COVID-19 strict home confinement on mental health and cognition in non-infected subjects (N = 16, 60-80 years) diagnosed with subjective cognitive decline and APOEɛ3/ɛ4 carriers. Mental health was monitored for 2 months on a daily, weekly, or monthly basis, and compared to pre-confinement values. Emotional distress, anxiety, and depression scores increased to pathological threshold values during and after confinement. Those with lower mood during confinement experienced a decline in their mood after confinement. Cognition did not change. These preliminary results suggest that mental health consequences of corona measures in preclinical stages of Alzheimer's disease should be further evaluated.application/pdfeng© 2021 – The authors. Published by IOS Press. This is an Open Access article distributed underthe terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0)info:eu-repo/semantics/articlehttp://dx.doi.org/10.3233/JAD-201408Alzheimer’s diseaseCOVID-19ConfinementMental healthSubjective cognitive declineinfo:eu-repo/semantics/openAccess