Rosa, AngeloDi Stefano, MarcoMicheletti, Cristian2020-03-242020-03-242019Rosa A, Di Stefano M, Micheletti C. Topological constraints in eukaryotic genomes and how they can be exploited to improve spatial models of chromosomes. Front Mol Biosci. 2019; 6:127. DOI: 10.3389/fmolb.2019.001272296-889Xhttp://hdl.handle.net/10230/44005application/pdfeng© 2019 Rosa, Di Stefano and Micheletti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.info:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fmolb.2019.00127DNA and chromosomesGenomic entanglementPhysical knots and linksStructural modelsTopological constraintsinfo:eu-repo/semantics/openAccess