Ivankov, Dmitry N.Finkelstein, Alexei V.Kondrashov, Fyodor A., 1979-2024-01-292024-01-292014Ivankov DN, Finkelstein AV, Kondrashov FA. A structural perspective of compensatory evolution. Current Opinion in Structural Biology. 2014 Jun;26:104-12. DOI: 10.1016/j.sbi.2014.05.0040959-440http://hdl.handle.net/10230/58840The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.application/pdfeng© 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).ProteïnesMolèculesAminoàcidsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.sbi.2014.05.004info:eu-repo/semantics/openAccess