Hardwick, MarcNolan, LukeNicoll, James A.R.Jogai, SanjayArriola Aperribay, EdurneJoseph-Pietras, DeboraNorman, JeanetteOttensmeier, Christian H.H.Galea, Ian2022-07-042022-07-042022Hardwick M, Nolan L, Nicoll JAR, Jogai S, Arriola E, Joseph-Pietras D, et al. CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer. Neuropathol Appl Neurobiol. 2022 Feb; 48(2): e12755. DOI: 10.1111/nan.127550305-1846http://hdl.handle.net/10230/53670We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.application/pdfengThis is an open access article under the terms of the Creative Commons Attribution License, http://creativecommons.org/licenses/by/4.0/which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/nan.12755CD8 T cellsCTLA-4 inhibitorCerebellitisImmune checkpoint inhibitorsIpilimumabParaneoplastic cerebellar degenerationinfo:eu-repo/semantics/openAccess