Tapia, JavierBasalo, MaríaEnjuanes Grau, CristinaCalero Molina, EstherJosé, NuriaRuíz, MartaCalvo, ElenaGarcimartín Cerezo, PalomaMoliner Borja, PedroHidalgo, EncarnacionYun, SergiGaray, AlbertoJiménez Marrero, SantiagoPons, AlexandraCorbella, XavierComín Colet, Josep2023-03-292023-03-292023Tapia J, Basalo M, Enjuanes C, Calero E, José N, Ruíz M, Calvo E, Garcimartín P, Moliner P, Hidalgo E, Yun S, Garay A, Jiménez-Marrero S, Pons A, Corbella X, Colet JC. Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients. ESC Heart Fail. 2023 Apr;10(2):1090-102. DOI: 10.1002/ehf2.142602055-5822http://hdl.handle.net/10230/56367Aims: There is little information about the influence of gender on quality of life (QoL) in heart failure. The purpose of this study was to evaluate whether the health-related QoL gap between men and women can be explained by the interaction between psychosocial factors and clinical determinants in a real-word cohort of patients with chronic heart failure. Methods and results: We conducted a single-centre, observational, prospective cohort study of 1236 consecutive patients diagnosed with chronic heart failure recruited between 2004 and 2014. To assess QoL, we used the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Female gender was associated with worse global QoL compared to male gender (MLHFQ overall summary score: 49 ± 23 vs. 43 ± 24; P value <0.001, respectively) and similarly had poorer scores in physical and emotional dimensions but scored better on social dimension. In univariate models and in models adjusted for clinical determinants, female gender behaved as a predictor of worse global, physical and emotional QoL, and better social QoL compared with men. In models only including psychosocial determinants and in comprehensive models including all psychosocial and clinical factors, these differences according to gender were no longer significant. Conclusions: In this study, we have shown that the gap in health-related QoL between men and women with chronic heart failure can be partially explained by the interaction between biological and psychosocial factors. Biological factors are the main drivers of QoL in HF patients. However, the contribution of psychosocial factors is essential to definitively understand the role of gender in this field.application/pdfeng© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/ehf2.14260GenderGeneric and specific questionnaires of quality of lifeHealth related quality of lifeHeart failureReal world evidenceinfo:eu-repo/semantics/openAccess