Nogués Solan, Francesc XavierOvejero Crespo, DianaPineda-Moncusí, MartaBouillon, RogerArenas Jiménez, María DoloresPascual Santos, JulioRibes, AnnaGuerri-Fernandez, RobertVillar García, JuditRial, AboraGimenez-Argente, CarmeCos, Maria LourdesRodriguez-Morera, JaimeCampodarve, IsabelQuesada-Gómez, J.M.García-Giralt, Natalia2022-03-082021Nogues X, Ovejero D, Pineda-Moncusí M, Bouillon R, Arenas D, Pascual J, Ribes A, Guerri-Fernandez R, Villar-Garcia J, Rial A, Gimenez-Argente C, Cos ML, Rodriguez-Morera J, Campodarve I, Quesada-Gomez JM, Garcia-Giralt N. Calcifediol treatment and COVID-19-related outcomes. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4017-e4027. DOI: 10.1210/clinem/dgab4050021-972Xhttp://hdl.handle.net/10230/52640Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims to elucidate the effect of 25(OH)D3 (calcifediol) treatment on COVID-19-related outcomes. Methods: This observational cohort study was conducted from March to May 2020, among patients admitted to COVID-19 wards of Hospital del Mar, Barcelona, Spain. A total of 930 patients with COVID-19 were included; 92 were excluded because of previous calcifediol intake. Of the remaining 838, a total of 447 received calcifediol (532 μg on day 1 plus 266 μg on days 3, 7, 15, and 30), whereas 391 were not treated at the time of hospital admission (intention-to-treat). Of the latter, 53 patients were treated later during ICU admission and were allocated in the treated group in a second analysis. In healthy individuals, calcifediol is about 3.2-fold more potent on a weight basis than cholecalciferol. Main outcome measures were ICU admission and mortality. Results: ICU assistance was required by 102 (12.2%) participants. Out of 447 patients treated with calcifediol at admission, 20 (4.5%) required the ICU, compared to 82 (21%) out of 391 nontreated (P < .001). Logistic regression of calcifediol treatment on ICU admission, adjusted by age, sex, linearized 25-hydroxyvitamin D levels at baseline, and comorbidities showed that treated patients had a reduced risk of requiring the ICU (odds ratio [OR] 0.13; 95% CI 0.07-0.23). Overall mortality was 10%. In the intention-to-treat analysis, 21 (4.7%) out of 447 patients treated with calcifediol at admission died compared to 62 patients (15.9%) out of 391 nontreated (P = .001). Adjusted results showed a reduced mortality risk with an OR of 0.21 (95% CI, 0.10-0.43). In the second analysis, the obtained OR was 0.52 (95% CI, 0.27-0.99). Conclusion: In patients hospitalized with COVID-19, calcifediol treatment significantly reduced ICU admission and mortality.application/pdfeng© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of clinical endocrinology and metabolism following peer review. The version of record Nogues X, Ovejero D, Pineda-Moncusí M, Bouillon R, Arenas D, Pascual J, Ribes A, Guerri-Fernandez R, Villar-Garcia J, Rial A, Gimenez-Argente C, Cos ML, Rodriguez-Morera J, Campodarve I, Quesada-Gomez JM, Garcia-Giralt N. Calcifediol treatment and COVID-19-related outcomes. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4017-e4027. DOI: 10.1210/clinem/dgab405 is available online at: https://academic.oup.com/jcem/article/106/10/e4017/6294179.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1210/clinem/dgab405COVID-19ICU admissionCalcifediolMortalityVitamin Dinfo:eu-repo/semantics/openAccess