Falcón, CarlesMinguillón, CarolinaFauria, KarineCascales Lahoz, DiegoContador, JoseFernández-Lebrero, AidaNavalpotro-Gómez, IrenePuig-Pijoan, AlbertGrau-Rivera, OriolSuárez-Calvet, MarcGispert López, Juan Domingo2025-10-032025-10-032024Falcon C, Montesinos P, Václavů L, Kassinopoulos M, Minguillon C, Fauria K, et al. Time-encoded ASL reveals lower cerebral blood flow in the early AD continuum. Alzheimers Dement. 2024 Aug;20(8):5183-97. DOI: 10.1002/alz.140591552-5260http://hdl.handle.net/10230/71351Introduction: Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer's disease (AD) patients. We checked the sensitivity of time-encoded arterial spin labeling (te-ASL) in measuring CBF alterations in individuals with positive AD biomarkers and associations with relevant biomarkers in cognitively unimpaired (CU) individuals. Methods: We compared te-ASL with single-postlabel delay (PLD) ASL in measuring CBF in 59 adults across the AD continuum, classified as CU amyloid beta (Aβ) negative (-), CU Aβ positive (+), and CI Aβ+. We sought associations of CBF with biomarkers of AD, cerebrovascular disease, synaptic dysfunction, neurodegeneration, and cognition in CU participants. Results: te-ASL was more sensitive at detecting CBF reduction in the CU Aβ+ and CI Aβ+ groups. In CU participants, lower CBF was associated with altered biomarkers of Aβ, tau, synaptic dysfunction, and neurodegeneration. Discussion: CBF reduction occurs early in the AD continuum. te-ASL is more sensitive than single-PLD ASL at detecting CBF changes in AD. Highlights: Lower CBF can be detected in CU subjects in the early AD continuum. te-ASL is more sensitive than single-PLD ASL at detecting CBF alterations in AD. CBF is linked to biomarkers of AD, synaptic dysfunction, and neurodegeneration.application/pdfeng© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/alz.14059Alzheimer's diseaseAmyloid betaMagnetic resonance imagingNeurodegenerationNeurofilament lightp‐tauSingle‐postlabel delay arterial spin labelingSynaptic dysfunctionTau proteinsinfo:eu-repo/semantics/openAccess