Altomare, DanieleGrau-Rivera, OriolGispert López, Juan DomingoMinguillón, CarolinaFrisoni, Giovanni B.AMYPAD Consortium2022-10-052022-10-052022Altomare D, Collij L, Caprioglio C, Scheltens P, van Berckel BNM, Alves IL, et al. Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD diagnostic and patient management study. Alzheimers Dement. 2022 Jun 17. DOI: 10.1002/alz.126961552-5260http://hdl.handle.net/10230/54264Data de publicació electrónica: 17-06-2022Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort. Methods: participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice. Results: A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms. Discussion: the features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.application/pdfengThis is an open access article under the terms of the Creative Commons Attribution- Non Commercial License http://creativecommons.org/licenses/by-nc/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. ©2022 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/alz.12696Alzheimer'sPETAmyloidDementiaMemory clinic populationMild cognitive impairmentSubjective cognitive declineinfo:eu-repo/semantics/openAccess