de Jesús-Gil, CarmenRuiz-Romeu, EsterFerran Farrés, MartaChiriac, AncaDeza Vargas, Luis GustavoHóllo, PéterCelada, AntonioPujol Vallverdú, Ramon MariaSantamaría-Babí, Luis Francisco2019-04-292019-04-292018De Jesús-Gil C, Ruiz-Romeu E, Ferran M, Chiriac A, Deza G, Hóllo P. et al. CLA+ T cell response to microbes in psoriasis. Front Immunol. 2018 Jun 27;9:1488. DOI: 10.3389/fimmu.2018.014881664-3224http://hdl.handle.net/10230/37141Streptococcus pyogenes throat infection is a clinically relevant trigger of both guttate and chronic plaque psoriasis, and it provides an ideal context in which to study the pathogenesis of these diseases using an antigen-dependent approach. Circulating cutaneous lymphocyte-associated antigen (CLA) positive (+) memory T cells are a subset of peripheral lymphocytes whose phenotype and function are related to immunological mechanisms in the skin. These cells are considered peripheral biomarkers of T-cell-mediated skin diseases. The coculture of autologous epidermal cells with CLA+ T cells from psoriasis patients activated by S. pyogenes allows the reproduction of the ex vivo initial molecular events that occur during psoriatic lesion formation. With cooperation of autologous epidermal cells, S. pyogenes selectively activates CLA+ T cells both in guttate and plaque psoriasis, inducing key mediators, including an IL-17 response. Here, we explore potential new mechanisms of psoriasis development including the influence of HLA-Cw6 on S. pyogenes CLA+ T cell activation in guttate psoriasis, the relevance of IL-9 on microbe induced IL-17 response in guttate and plaque psoriasis, and novel effector functions of Candida albicans. This review will summarize recent knowledge of psoriatic mechanisms elicited by microbes that have been studied through an innovative translational perspective based on CLA+ T cell-mediated cutaneous immune response.application/pdfeng© 2018 De Jesús-Gil, Ruiz-Romeu, Ferran, Chiriac, Deza, Hóllo, Celada, Pujol and Santamaria-Babí. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Psoriasiinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fimmu.2018.01488Candida albicansStreptococcus pyogenesCutaneous lymphocyte-associated antigenHomingPsoriasisinfo:eu-repo/semantics/openAccess