Giordano, AntonioCompañy, LuisAlajarin-Cervera, MiriamRuiz-Gómez, Francisco AntonioFernández-Gil, Pedro LuisAlonso-Lázaro, NoeliaSola-Vera, JavierUrpi-Ferreruela, MiguelAicart-Ramos, MartaParejo-Carbonell, SofíaDedeu Cusco, Josep MariaPrieto-Frías, CésarBógalo-Romero, CintiaEgea-Valenzuela, JuanCarretero, CristinaPons-Beltrán, VicenteGonzález-Suarez, Begoña2025-07-172025-07-172024Giordano A, Compañy L, Alajarin-Cervera M, Ruiz-Gómez FA, Fernández-Gil PL, Alonso-Lázaro N, et al. Prospective multicenter study to identify optimal target population for motorized spiral enteroscopy. Sci Rep. 2024 Jul 22;14(1):16788. DOI: 10.1038/s41598-024-64510-w2045-2322http://hdl.handle.net/10230/70943Motorized spiral enteroscopy (MSE) enhances small bowel exploration, but the optimal target population for this technique is unknown. We aimed to identify the target population for MSE by evaluating its efficacy and safety, as well as detecting predictors of efficacy. A prospective multicenter observational study was conducted at 9 tertiary hospitals in Spain, enrolling patients between June 2020-2022. Analyzed data included demographics, indications for the procedure, exploration time, depth of maximum insertion (DMI), technical success, diagnostic yield, interventional yield, and adverse events (AE) up to 14 days from enteroscopy. Patients with prior gastrointestinal surgery, unsuccessful balloon enteroscopy and small bowel strictures were analyzed. A total of 326 enteroscopies (66.6% oral route) were performed in 294 patients (55.1% males, 65 years ± 21). Prior abdominal surgery was present in 50% of procedures (13.5% gastrointestinal surgery). Lower DMI (162 vs 275 cm, p = 0.037) and diagnostic yield (47.7 vs 67.5%, p = 0.016) were observed in patients with prior gastrointestinal surgery. MSE showed 92.2% technical success and 56.9% diagnostic yield after unsuccessful balloon enteroscopy (n = 51). In suspected small bowel strictures (n = 49), the finding was confirmed in 23 procedures (46.9%). The total AE rate was 10.7% (1.8% classified as major events) with no differences related to prior gastrointestinal/abdominal surgery, unsuccessful enteroscopy, or suspected small bowel strictures. The study demonstrates that MSE has a lower diagnostic yield and DMI in patients with prior gastrointestinal surgery but is feasible after unsuccessful balloon-enteroscopy and in suspected small bowel strictures without safety concerns.application/pdfeng© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-024-64510-wGastroenterologySmall intestineinfo:eu-repo/semantics/openAccess