Palomer, ErnestIll-Raga, Gerard, 1982-Tajes Orduña, MartaRamos Fernández, Eva, 1984-Bosch Morató, Mònica, 1986-Guivernau Almazán, Biuse, 1988-Galán, José JClarimón Echevarría, JordiAntúnez, CarmenBoada, MercèReal, Luis MFandos, CésarMuñoz López, Francisco José, 1964-2016-04-202016-04-202011Palomer E, Ill-Raga G, Tajes M, Ramos-Frnández E, Bosch-Morató M, Guivernau B et al. PKR and PP1C polymorphisms in alzheimer’s disease risk. Neuroscience & Medicine. 2011;2(3):226-31. DOI: 10.4236/nm.2011.230312158-2912http://hdl.handle.net/10230/26137Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ß-peptide (Aß) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ß-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.application/pdfeng© 2011 SciResAlzheimer, Malaltia d'info:eu-repo/semantics/articlehttp://dx.doi.org/10.4236/nm.2011.23031Alzheimer’s DiseaseBACE1PKRPP1eIF2αinfo:eu-repo/semantics/openAccess