Mijimolle, NievesVelasco, JuanDubus, PierreGuerra, CarmenWeinbaum, Carolyn A.Casey, Patrick J.Campuzano Uceda, María VictoriaBarbacid, Mariano2016-02-182016-02-182005Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ et al. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer cell. 2005;7(4):313-24. DOI: 10.1016/j.ccr.2005.03.0041535-6108http://hdl.handle.net/10230/25884Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.application/pdfeng© Elsevier. This is the published version of an article http://dx.doi.org/10.1016/j.ccr.2005.03.004 that appeared in the journal Cancer cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseHomeòstasiTumorsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ccr.2005.03.004info:eu-repo/semantics/openAccess