Silva Doria, Pedro LeopoldoMoscovitz, ThomasTcherniakovsky, MarcosFernandes, Cesar EduardoPompei, Luciano MeloWajman, MiltonNimwegen, Angela VanHaimovich Segal, Sergio Mario2019-03-112019-03-112018Silva-Doria PL, Moscovitz T, Tcherniakovsky M, Fernandes CE, Pompei LM, Wajman M. et al. Association of IGF-1 CA(n) and IGFBP3 rs2854746 polymorphisms with endometrial polyp risk. Biomed Res Int. 2018 Dec 13; 2018:8704346. DOI: 10.1155/2018/87043462314-6141http://hdl.handle.net/10230/36786INTRODUCTION: Insulin-like growth factor 1 (IGF-1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF-1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). Genetic variations influence the levels of IGF-1 and IGFBP3. The purpose of this study was to examine the association of polymorphisms IGF-1 CA(n) and IGFBP3 rs2854746 with risk of endometrial polyps. MATERIALS AND METHODS: Case control observational study, composed of 104 women with antecedent of endometrial polyp (case group) and 81 postmenopausal women without antecedent of endometrial diseases (control group). Genotyping of IGF-1 CA(n) was performed by PCR and fragment analysis by capillary electrophoresis, and genotyping of IGFBP3 rs2854746 was performed by PCR-HRM. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression. RESULTS: The genotype IGF-1 CA(19)/CA(19) was associated with an increased endometrial polyp risk (OR=2,57; IC 95%= 1,09 - 6,01); this was also found when combining it with CA(>19)/CA(n) genotypes (OR=2,18; IC 95%= 1,06-4,47). The IGFBP3 rs2854746 analyses showed the CG genotype having a protective effect for endometrial polyp (OR=0,37; IC 95%= 0,19-0,73), fact also observed when grouping CG and GG carriers (OR=0,51; IC 95%= 0,28-0,93). CONCLUSION: The genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk.application/pdfengCopyright © 2018 Pedro Leopoldo Silva Doria et al. This is an open access article distributed under the https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Pòlips (Patologia)Endometri--Malalties--DiagnòsticGenotipinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2018/8704346info:eu-repo/semantics/openAccess