Klosin, AdamCasas, EduardHidalgo-Carcedo, CristinaVavouri, TanyaLehner, Ben, 1978-2019-03-082019-03-082017Klosin A, Casas E, Hidalgo-Carcedo C, Vavouri T, Lehner B. Transgenerational transmission of environmental information in C. elegans. Science. 2017 Apr 21;356(6335):320-3. DOI: 10.1126/science.aah64120036-8075http://hdl.handle.net/10230/36780The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis elegans heterochromatic gene array can endure for at least 14 generations. Inheritance is primarily in cis with the locus, occurs through both oocytes and sperm, and is associated with altered trimethylation of histone H3 lysine 9 (H3K9me3) before the onset of zygotic transcription. Expression profiling reveals that temperature-induced expression from endogenous repressed repeats can also be inherited for multiple generations. Long-lasting epigenetic memory of environmental change is therefore possible in this animal.application/pdfengThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on Volume 356 number 6335, 2017. DOI: 10.1126/science.aah6412Caenorhabditis elegansMedi ambientEpigenèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/science.aah6412info:eu-repo/semantics/openAccess