Deza Vargas, Luis GustavoGarcía-Colmenero, LidiaCurto Barredo, LaiaPujol Vallverdú, Ramon MariaGiménez Arnau, Anna Maria2016-09-022016-09-022016Deza G, García-Colmenero L, Curto-Barredo L, Pujol RM, Giménez-Arnau AM. Management of Chronic Spontaneous Urticaria Exacerbated by Antihistamines: When Treatment Can Act as a Causal Agent Itself. Acta Derm Venereol. 2016 Aug 23;96(6):838-9. doi: 10.2340/00015555-24030001-5555http://hdl.handle.net/10230/27273AlthoughH1- antihistaminescurrentlyconstitutethelargestclassofmedicationsusedinthetreatmentofallergicdisorders,somecasesofhypersensitivityreactionsduetovariousantihistaminepreparations,suchasfixeddrugeruptions,contactdermatitis,maculo- papularrash,andurticarialreactions,havebeenreported(1).Wereporthereintwopatientswithchronicspontaneousurticaria(CSU)inwhichantihistaminesactedasexacerbatingfactorsofthediseaseandrequiredanalternativetreatment.Theunderlyingmechanismintheseparticularcasesisnotentirelyclear,butatype-I(immediate)hypersensitivityreactionshouldbeconsideredapplication/pdfeng© 2016 The Authors. doi: 10.2340/00015555-2403UrticàriaAntihistamínicsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.2340/00015555-2403info:eu-repo/semantics/openAccess