Herrmann, MadeleineRuprecht, KlemensSauter, MarliesMartinez, Javier P.van Heteren, PearlGlas, MichaelBest, BarbaraMeyerhans, AndreasRoemer, KlausMueller-Lantzsch, Nikolaus2016-01-152016-01-152010Herrmann M, Ruprecht K, Sauter M, Martinez J, van Heteren P, Glas M et al. Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1. FEBS Letters. 2010;584(16):3513-8. DOI: 10.1016/j.febslet.2010.07.0160014-5793http://hdl.handle.net/10230/25585Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) to the cytoplasmic C-terminus of the voltage-gated potassium channel BEC1 (brain-specific ether-a-go-go-like channel 1), an interaction that can result in the repression of BEC's activity and the inhibition of HIV-1 particle-release. BEC1 protein was found to be expressed in T cells and macrophages, the major target cells of HIV-1. Thus, gp120/BEC1 interaction may be involved in HIV-1 life cycle and/or pathogenesis.application/pdfeng© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.febslet.2010.07.016 that appeared in the journal FEBS Letters. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseVIH (Virus)RNA missatgerinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.febslet.2010.07.016Human immunodeficiency virusImmunodeficiency virusGlycoprotein 120info:eu-repo/semantics/openAccess