Couto-Silva, Cainã M.Nunes, KellyVenturini, GabrielaCastro e Silva, Marcos AraújoPereira, Lygia V.Comas, David, 1969-Pereira, Alexandre C.Hünemeier, Tábita2023-03-222023-03-222023Couto-Silva CM, Nunes K, Venturini G, Araújo Castro E Silva M, Pereira LV, Comas D, Pereira A, Hünemeier T. Indigenous people from Amazon show genetic signatures of pathogen-driven selection. Sci Adv. 2023 Mar 10;9(10):eabo0234. DOI: 10.1126/sciadv.abo02342375-2548http://hdl.handle.net/10230/56315Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. This study investigates the possible footprints of genetic adaptation to the Amazon rainforest environment by analyzing the genomic data of 19 native populations. The results based on genomic and functional analysis showed an intense signal of natural selection in a set of genes related to Trypanosoma cruzi infection, which is the pathogen responsible for Chagas disease, a neglected tropical parasitic disease native to the Americas that is currently spreading worldwide.application/pdfeng© 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1126/sciadv.abo0234info:eu-repo/semantics/openAccess