Iron depletion in systemic and muscle compartments defines a specific phenotype of severe COPD in female and male patients: Implications in exercise tolerance

Pérez-Peiró, MariaAlvarado, MarielaMartín-Ontiyuelo, ClaraDuran Jordà, Xavier, 1974-Rodríguez Chiaradía, Diego AgustínBarreiro Portela, Esther2023-05-052023-05-052022Pérez-Peiró M, Alvarado M, Martín-Ontiyuelo C, Duran X, Rodríguez-Chiaradía DA, Barreiro E. Iron depletion in systemic and muscle compartments defines a specific phenotype of severe COPD in female and male patients: Implications in exercise tolerance. Nutrients. 2022 Sep 22;14(19):3929. DOI: 10.3390/nu141939292072-6643http://hdl.handle.net/10230/56680We hypothesized that iron content and regulatory factors, which may be involved in exercise tolerance, are differentially expressed in systemic and muscle compartments in iron deficient severe chronic obstructive pulmonary disease (COPD) patients. In the vastus lateralis and blood of severe COPD patients with/without iron depletion, iron content and regulators, exercise capacity, and muscle function were evaluated in 40 severe COPD patients: non-iron deficiency (NID) and iron deficiency (ID) (20 patients/group). In ID compared to NID patients, exercise capacity, muscle iron and ferritin content, serum transferrin saturation, hepcidin-25, and hemojuvelin decreased, while serum transferrin and soluble transferrin receptor and muscle IRP-1 and IRP-2 increased. Among all COPD, a significant positive correlation was detected between FEV1 and serum transferrin saturation. In ID patients, significant positive correlations were detected between serum ferritin, hepcidin, and muscle iron content and exercise tolerance and between muscle IRP-2 and serum ferritin and hepcidin levels. In ID severe COPD patients, iron content and its regulators are differentially expressed. A potential crosstalk between systemic and muscle compartments was observed in the ID patients. Lung function and exercise capacity were associated with several markers of iron metabolism regulation. Iron status should be included in the overall assessment of COPD patients given its implications in their exercise performance.application/pdfeng© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Iron depletion in systemic and muscle compartments defines a specific phenotype of severe COPD in female and male patients: Implications in exercise toleranceinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/nu14193929Implications in exercise toleranceIron metabolism regulationIron-deficient patientsPathophysiology of iron regulationSevere chronic obstructive pulmonary diseaseSystemic manifestations of chronic diseasesinfo:eu-repo/semantics/openAccess