Brotons, PedroJordan, IolandaBassat, QuiqueHenares, DesireeFernandez de Sevilla, MarionaAjanovic, SaraRedin, AlbaFumadó, VictoriaBaró, BàrbaraClaverol, JoanaVaro, RosauroCuadras, DanielHecht, JochenBarrabeig, IreneGarcia-Garcia, Juan JoseLaunes, CristianMuñoz-Almagro, Carmen2021-12-142021-12-142021Brotons P, Jordan I, Bassat Q, Henares D, Fernandez de Sevilla M, Ajanovic S et al. The positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance study. Viruses. 2021 Aug 12;13(8):1598. DOI: 10.3390/v130815981999-4915http://hdl.handle.net/10230/49202We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.application/pdfeng© 2021 by Pedro Brotons et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)COVID-19 (Malaltia)RinovirusThe positive rhinovirus/enterovirus detection and SARS-CoV-2 persistence beyond the acute infection phase: an intra-household surveillance studyinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v13081598info:eu-repo/semantics/openAccess