Secolin, RodrigoMas Sandoval, Àlex, 1989-Arauna, Lara RTorres, Fábio R.de Araujo, Tânia K.Santos, Marilza L.Rocha, Cristiane S.Carvalho, Benilton S.Cendes, FernandoLopes-Cendes, IsciaComas, David, 1969-2019-11-072019-11-072019Secolin R, Mas-Sandoval A, Arauna LR, Torres FR, de Araujo TK, Santos ML et al. Distribution of local ancestry and evidence of adaptation in admixed populations. Sci Rep. 2019;9(1):13900. DOI: 10.1038/s41598-019-50362-22045-2322http://hdl.handle.net/10230/42784Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events.application/pdfeng© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/s41598-019-50362-2Evolutionary biologyGeneticsinfo:eu-repo/semantics/openAccess