Nadal Ribelles, Mariona, 1984-Solé, CarmeXu, ZhenyuSteinmetz, Lars M.Nadal Clanchet, Eulàlia dePosas Garriga, Francesc2015-06-162015-06-162014Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F. Control of Cdc28 CDK1 by a stress-induced lncRNA. Molecular Cell. 2014;53(4):549-61. DOI: 10.1016/j.molcel.2014.01.0061097-2765http://hdl.handle.net/10230/23826Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon environmental changes. Upon osmostress, hundreds of stress-responsive genes are induced by the stress-activated protein kinase (SAPK) p38/Hog1. Using whole-genome tiling arrays, we found that Hog1 induces a set of lncRNAs upon stress. One of the genes expressing a Hog1-dependent lncRNA in antisense orientation is CDC28, the cyclin-dependent kinase 1 (CDK1) that controls the cell cycle in yeast. Cdc28 lncRNA mediates the establishment of gene looping and the relocalization of Hog1 and RSC from the 3′ UTR to the +1 nucleosome to induce CDC28 expression. The increase in the levels of Cdc28 results in cells able to reenter the cell cycle more efficiently after stress. This may represent a general mechanism to prime expression of genes needed after stresses are alleviated.application/pdfeng© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.molcel.2014.01.006 that appeared in the journal Molecular Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseProteïnes quinases -- MetabolismeSaccharomyces cerevisiae -- MetabolismeTranscripció genèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.molcel.2014.01.006info:eu-repo/semantics/openAccess