Slebe Concha, Juan Felipe, 1981-Rojo, FedericoVinaixa, MariaGarcía-Rocha, MarTestoni, GiorgiaGuiu, MarcPlanet, EvaristSamino, SaraArenas, Enrique J.Beltran Marqués, AntoniRovira Guerín, AnaLluch, AnaSalvatella, XavierYanes, OscarAlbanell Mestres, JoanGuinovart, Joan J. (Joan Josep), 1947-Gomis, Roger R.2016-07-202016-07-202016Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M et al. FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nat Commun. 2016 Apr 5;7:11199. DOI: 10.1038/ncomms111992041-1723http://hdl.handle.net/10230/27092The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.application/pdfengThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Càncer -- Aspectes genèticsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/ncomms11199info:eu-repo/semantics/openAccess