Lidón-Moyano, CristinaFu, MarcelaPérez Ortuño, Raúl, 1976-Ballbé, MontseGarcía, EsteveMartín-Sánchez, Juan CarlosPascual Esteban, José A.Fernández, EsteveMartínez-Sánchez, Jose M.2021-06-222021Lidón-Moyano C, Fu M, Pérez-Ortuño R, Ballbè M, Garcia E, Martín-Sánchez JC, et al. Third-hand exposure at homes: assessment using salivary cotinine. Environ Res. 2021 May; 196: 110393. DOI: 10.1016/j.envres.2020.1103930013-9351http://hdl.handle.net/10230/47956Background/objectives: While exposure to secondhand smoke (SHS) is a well-established problem, exposure to third-hand smoke (THS) is scanty known and needs to be studied. The objective of this work is to characterize salivary cotinine concentrations among people who self-reported exposure to SHS and THS at home. Methods: Cross-sectional study of a representative sample (n = 736) of the adult population (≥16 years) from the city of Barcelona carried out in 2013-2014. A questionnaire on tobacco use and passive exposure was administered, and a saliva sample was collected for cotinine determination. For this study, the information of the non-smoker participants who provided saliva sample (n = 519) was used. The geometric means (GM) and geometric standard deviations (GSD) of the cotinine concentration were compared according to the type of self-reported exposure at home: (1) Not exposed to SHS or THS; (2) Exposed to SHS and THS; and (3) Only exposed to THS. We used log-linear models to compare the cotinine concentration of each exposed group with respect to the unexposed group, adjusting for sex, age, educational level, and tobacco exposure in other settings. Results: The GM of the salivary cotinine concentration was 0.34 ng/ml (GSD = 0.16) among individuals reporting SHS and THS exposure, 0.22 ng/ml (GSD = 0.15) among those reporting only THS exposure and 0.11 ng/ml (GSD = 0.04) among those who declared not to be exposed to SHS nor THS (p-value for trend <0.001). The regression model showed a statistically significant increase in cotinine concentration among those exposed to SHS and THS (188% higher, 95% CI: 153%; 223%), and only exposed to THS (106% higher, IC95. %: 74.5%; 137.0%) when comparing with the unexposed group. No statistically significant differences in cotinine concentration were observed between those exposed to SHS and THS compared to the THS group (-25.8%, 95% CI: -69.5%; 17.9%). Conclusions/recommendations: People exposed to third-hand smoke at home had quantifiable cotinine levels in saliva. No differences in cotinine levels were found between those exposed to second-hand and third-hand smoke at home. The reduction of exposure to third-hand smoke at home should be put into the agenda of tobacco control.application/pdfeng© Elsevier http://dx.doi.org/10.1016/j.envres.2020.110393info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.envres.2020.110393BiomarkerSmoke-free homesThird-hand smokeTobacco exposureinfo:eu-repo/semantics/openAccess