Meyer, MarkusVilardell, Josep2012-04-182012-04-182009Meyer M, Vilardell J. The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Brief Funct Genomic Proteomic. 2009;8(1):60-7. DOI: 10.1093/bfgp/elp0021473-9550http://hdl.handle.net/10230/16373Removal of introns during pre-mRNA splicing is a critical process in gene expression, and understanding its control at both single-gene and genomic levels is one of the great challenges in Biology. Splicing takes place in a dynamic, large ribonucleoprotein complex known as the spliceosome. Combining Genetics and Biochemistry, Saccharomyces cerevisiae provides insights into its mechanisms, including its regulation by RNA-protein interactions. Recent genome-wide analyses indicate that regulated splicing is broad and biologically relevant even in organisms with a relatively simple intronic structure, such as yeast. Furthermore, the possibility of coordination in splicing regulation at genomic level is becoming clear in this model organism. This should provide a valuable system to approach the complex problem of the role of regulated splicing in genomic expression.application/pdfeng© 2009 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Briefings in Functional Genomics and Proteomics following peer review. The definitive publisher-authenticated version Meyer M, Vilardell J. The quest for a message: budding yeast, a model organism to study the control of pre-mRNA splicing. Brief Funct Genomic Proteomic. 2009; 8(1):60-7 is available online at: http://bfg.oxfordjournals.org/content/8/1/60.longARN empalmamentRegulació genèticainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1093/bfgp/elp002Regulated splicingRNAYeastGenomicsMicroarraysinfo:eu-repo/semantics/openAccess