Horcajada Gallego, Juan Pablode Pablo-Miró, MarPujol-Ruiz¸ SergiIftimie, Simona MihaelaArenas-Miras, María Del MarLópez Montesinos, InmaculadaDuran Jordà, Xavier, 1974-Anglès, AlbertGrau Cerrato, SantiagoHorcajada Gallego, Juan Pablo2022-07-182022-07-182021de Pablo-Miró M, Pujol-Ruiz S, Iftimie S, Arenas-Miras MDM, López-Montesinos I, Duran-Jordà X, et al. Comparative analysis of dalbavancin versus other antimicrobial options for gram-positive cocci infections: effectiveness, hospital stay and mortality. Antibiotics (Basel). 2021 Oct 24; 10(11): 1296. DOI: 10.3390/antibiotics101112962079-6382http://hdl.handle.net/10230/53753Dalbavancin is a new antibiotic that is effective against Gram-positive microorganisms, including methicillin-resistant Staphylococci, and offers the possibility of administering intravenous therapy once weekly in an ambulatory setting. We conducted a multicenter observational case-control study, comparing all patients who received dalbavancin (cases) with hospitalized patients who were treated instead with daptomycin, linezolid or vancomycin (controls), based on clinical diagnosis, main microorganism involved, and age. The primary outcome was the length of hospital stay after starting the study antimicrobial. Secondary outcomes were 7-day and 30-day efficacy, 30-day mortality, 90-day recurrence, 90-day and 6-month hospitalization, presence of adverse events and healthcare-associated infections; 161 patients (44 cases and 117 controls) were included. Bivariate analysis showed that dalbavancin reduced the total length of hospital stay (p < 0.001), with fewer 90-day recurrences (p = 0.005), 6-month hospitalizations related to the same infection (p = 0.004) and non-related hospitalizations (p = 0.035). Multivariate analyses showed that length of hospital stay was significantly shorter in patients treated with dalbavancin (-12.05 days 95% CI [-17.00, -7.11], p < 0.001), and 30-day efficacy was higher in the dalbavancin group (OR 2.62 95% CI [1.07, 6.37], p = 0.034). Although sample size of the study may be a limitation, we can conclude that Dalbavancin is a useful antimicrobial drug against Gram-positive infections, including multidrug-resistant pathogens, and allows for a remarkable reduction in length of hospital stay with greater 30-day efficacy.application/pdfengCopyright © 2021 by Mar de Pablo-Miró. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/antibiotics10111296DalbavancinEffectivenessGram-positiveHospital stayMethicillin-resistant staphylococciMortalityMultidrug-resistant gram-positive cocciinfo:eu-repo/semantics/openAccess