Sazonov, IgorGrebennikov, DmitrySavinkov, RostislavSoboleva, ArinaPavlishin, KirillMeyerhans, AndreasBocharov, Gennady A.2023-05-292023-05-292023Sazonov I, Grebennikov D, Savinkov R, Soboleva A, Pavlishin K, Meyerhans A, Bocharov G. Stochastic modelling of HIV-1 replication in a CD4 T cell with an IFN response. Viruses. 2023 Jan 20;15(2):296. DOI: 10.3390/v150202961999-4915http://hdl.handle.net/10230/57002A mathematical model of the human immunodeficiency virus Type 1 (HIV-1) life cycle in CD4 T cells was constructed and calibrated. It describes the activation of the intracellular Type I interferon (IFN-I) response and the IFN-induced suppression of viral replication. The model includes viral replication inhibition by interferon-induced antiviral factors and their inactivation by the viral proteins Vpu and Vif. Both deterministic and stochastic model formulations are presented. The stochastic model was used to predict efficiency of IFN-I-induced suppression of viral replication in different initial conditions for autocrine and paracrine effects. The probability of virion excretion for various MOIs and various amounts of IFN-I was evaluated and the statistical properties of the heterogeneity of HIV-1 and IFN-I production characterised.application/pdfeng© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v15020296HIV life cycleMarkov chain Monte Carlo methodType I interferon (IFN-I)Mathematical modelSensitivity analysisStochastic processesViral dynamicsinfo:eu-repo/semantics/openAccess