Fagundo, Ana B.Torre Fornell, Rafael de laFernández Aranda, Fernando2016-12-072016-12-072016Fagundo AB, Jiménez-Murcia S, Giner-Bartolomé C, Agüera Z, Sauchelli S, Pardo M. et al. Modulation of irisin and physical activity on executive functions in obesity and morbid obesity. Sci Rep. 2016 Aug 1;6:30820. doi: 10.1038/srep308202045-2322http://hdl.handle.net/10230/27715Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use.application/pdfeng© 2016, The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ObesitatExercici -- Aspectes fisiològicsObesitat mòrbidainfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1038/srep30820info:eu-repo/semantics/openAccess