Mulero, María CarmenIslam, Abul, 1978-Margalef González, Pol, 1985-Pecoraro, Matteo, 1984-Toll Abelló, AgustínDrechsel, Nils Jan Daniel, 1980-Charneco, CristinaBellora Pereyra, NicolásGallardo Hernández, FernandoLópez Arribillaga, Erika, 1986-Asensio Juan, ElenaRodilla, VerónicaGonzález, JessicaIglesias Coma, MarAlbà Soler, MarDi Croce, LucianoVillà i Freixa, JordiLópez Bigas, NúriaKeyes, William M., 1973-Bigas Salvans, AnnaEspinosa Blay, Lluís2015-11-252015-11-252013Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A et al. Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 2013; 24(2): 151-166. DOI 10.1016/j.ccr.2013.06.0031535-6108http://hdl.handle.net/10230/25227IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imparts their competence to be activated by TNF-alpha. Mutations in the Drosophila IκBα gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-κB. Oncogenic transformation of keratinocytes results in cytoplasmic IκBα translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IκBα was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation.application/pdfeng© Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.ccr.2013.06.003 that appeared in the journal Cancer Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseCèl·lulesPellTumorsinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ccr.2013.06.003info:eu-repo/semantics/openAccess