Mochol, GabrielaKiryk, AnnaMochol, GabrielaFilipkowski, Robert K.Wawrzyniak, MarcinLioudyno, VictoriaKnapska, EwelinaGorkiewicz, TomaszBalcerzyk, MarcinLeski, SzymonVan Leuven, FredLipp, Hans-PeterWójcik, Daniel K.Kaczmarek, Leszek2018-07-232018-07-232011Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Curr Alzheimer Res. 2011;8(8):883-92. DOI: 10.2174/1567205117981927451567-2050http://hdl.handle.net/10230/35238In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.application/pdfeng© Bentham Science Publishers. Article published in Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/89141/articleinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.2174/156720511798192745Circadian rhythmGroup learningIndividual learningIntelliCageSocial behaviorAmyloid precursor proteinIntelliCage systemAgeingSensorimotorinfo:eu-repo/semantics/openAccess