Karachaliou, MariannaRanzani, OtavioEspinosa Díaz, AnaIraola Guzmán, SusanaCastaño Vinyals, GemmaVidal, MartaJiménez, AlfonsBañuls, MarcAlonso Nogués, EvaAguilar, RuthGarcía Aymerich, JudithCid Ibeas, Rafael deDobaño, CarlotaMoncunill, GemmaKogevinas, Manolis2024-11-132024-11-132024Karachaliou M, Ranzani O, Espinosa A, Iraola-Guzmán S, Castaño-Vinyals G, Vidal M, et al. Antibody responses to common viruses according to COVID-19 severity and postacute sequelae of COVID-19. J Med Virol. 2024 Sep;96(9):e29862. DOI: 10.1002/jmv.298620146-6615http://hdl.handle.net/10230/68507Limited research suggests that certain viruses reactivate in severe-acute-respiratory-syndrome-coronavirus 2 infection, contributing to the development of postacute sequelae of COVID-19 (PASC). We examined 1083 infected individuals from a population-based cohort, and assessed differences in plasma immunoglobulin (Ig)G and immunoglobulin A levels against Epstein-Barr virus (EBV), cytomegalovirus, varicella zoster virus (VZV), BK polyomavirus, KI polyomavirus, WU polyomavirus (WUPyV), respiratory syncytial virus, and Adv-36 according to the severity of previous COVID-19 and PASC history. Individuals who had experienced severe COVID-19 had higher antibody responses to latent viruses. Ever PASC, active persistent PASC, and PASC with neuropsychiatric symptoms were associated with higher immnoglobulin G to EBV early antigen-diffuse, VZV, and WUPyV even among individuals without previous severe COVID-19.application/pdfeng© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/jmv.29862COVID‐19HerpesvirusesLong COVIDPolyomavirusesPostacute sequelae of COVID‐19info:eu-repo/semantics/openAccess