Montagni, ElenaResta, FrancescoTort-Colet, NúriaScaglione, AlessandroMazzamuto, GiacomoDestexhe, AlainPavone, Francesco SaverioAllegra Mascaro, Anna Letizia2025-06-042025-06-042024Montagni E, Resta F, Tort-Colet N, Scaglione A, Mazzamuto G, Destexhe A, et al. Mapping brain state-dependent sensory responses across the mouse cortex. iScience. 2024 Apr 9;27(5):109692. DOI: 10.1016/j.isci.2024.1096922589-0042http://hdl.handle.net/10230/70606Sensory information must be integrated across a distributed brain network for stimulus processing and perception. Recent studies have revealed specific spatiotemporal patterns of cortical activation for the early and late components of sensory-evoked responses, which are associated with stimulus features and perception, respectively. Here, we investigated how the brain state influences the sensory-evoked activation across the mouse cortex. We utilized isoflurane to modulate the brain state and conducted wide-field calcium imaging of Thy1-GCaMP6f mice to monitor distributed activation evoked by multi-whisker stimulation. Our findings reveal that the level of anesthesia strongly shapes the spatiotemporal features and the functional connectivity of the sensory-activated network. As anesthesia levels decrease, we observe increasingly complex responses, accompanied by the emergence of the late component within the sensory-evoked response. The persistence of the late component under anesthesia raises new questions regarding the potential existence of perception during unconscious states.application/pdfeng© 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)info:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.isci.2024.109692NeuroscienceSensory neuroscienceinfo:eu-repo/semantics/openAccess