Kharraz, YacineGuerra, JoanaPessina, PatriziaSerrano, Antonio L.Muñoz Cánoves, Pura, 1962-2015-05-252015-05-252014Kharraz Y, Guerra J, Pessina P, Serrano AL, Muñoz-Canoves P. Understanding the process of fibrosis in duchenne muscular dystrophy. BioMed Research International. 2014;2014:965631. DOI: 10.1155/2014/9656312314-6133http://hdl.handle.net/10230/23634Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur in a large variety of vital organs and tissues, including skeletal muscle. In human muscle, fibrosis is most readily associated with the severe muscle wasting disorder Duchenne muscular dystrophy (DMD), caused by loss of dystrophin gene function. In DMD, skeletal muscle degenerates and is infiltrated by inflammatory cells and the functions of the muscle stem cells (satellite cells) become impeded and fibrogenic cells hyperproliferate and are overactivated, leading to the substitution of skeletal muscle with nonfunctional fibrotic tissue. Here, we review new developments in our understanding of the mechanisms leading to fibrosis in DMD and several recent advances towards reverting it, as potential treatments to attenuate disease progression.application/pdfengCopyright © 2014 Yacine Kharraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Distròfia muscularCèl·lules satèlitinfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1155/2014/965631info:eu-repo/semantics/openAccess